At this time, there are two styles of scientific tests on itaconate: Irg1−/− macrophages along with the regulatory effect of itaconate derivatives. These two results ended up complementary and exposed the regulatory mechanisms of itaconate associated alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription aspect three (ATF3) https://tomo741axv7.bmswiki.com/user