Pentobarbital will lower the level or effect of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known. pentobarbital will lower the level or effect of amiodarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. pentobarbital will reduce the level or result of etonogestrel by affecting hepatic/intestinal enzyme C... https://is-nembutal-a-cns-depress62693.suomiblog.com/considerations-to-know-about-is-nembutal-a-depressant-46754770