Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, ... https://carolynh218fnw6.thechapblog.com/profile