Pentobarbital will reduce the level or impact of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Powerful or reasonable CYP3A4 inducers significantly lessen guanfacine plasma concentrations and elimination half-life. pentobarbital will increase effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Check. C... https://oweno123fdy1.wikiinside.com/user